Sarah Ford | August 28, 2015
Diabetes Research Institute Successfully Transplants First Patient in BioHub Trial
After receiving a call from the Diabetes Research Institute’sClinical Cell Transplant Team, Wendy Peacock became the first patienttransplanted in DRI’s FDA-approvedPhase I/II clinical trial to test the omentum as a new implant sitefor a DRI, a bioengineered “mini-organ” that mimics the native pancreas to restore natural insulin production in people with type 1 diabetes.
In thisfirst-ever clinical trial, researchers will evaluate whether the omentum is a better home for the islets than the liver, thetraditional transplant site. The donor islet cells wereimplanted using a biologic, fully re-absorbable scaffold technique – referred to as a“biodegradable scaffold,” one of the DRI BioHub platforms. This scaffold is a combination of the patient’s own plasma, the liquid part of the blood that does not contain any cells, together with thrombin, a commonly-used, clinical-grade enzyme.
The DRI’s preliminary findings have shown that islets in the omentum can survive and function long term. This clinical trialis an important first step in identifying an optimal location in the body for a DRI BioHub.
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